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Vitamin B12 injection dosage recommendations may vary significantly depending on a number of factors including the cause and degree of B12 deficiency, its manifestations and the age and sex of the patient.
Typically, treatment will start with high dosing in the initial weeks and is then followed by monthly maintenance B12 shots.
The required dosage amounts may vary with the diagnosis.
For example, if B12 deficiency symptoms have shown neurological involvement, the initial treatment is likely to start with 1,000 microgram injections on alternating days for several weeks.
However, in the absence of neurologic symptoms the initial vitamin B12 injection dosage may be as low 250 micrograms on alternate days for 2 weeks.
And treatment for B12 related anemia might only require monthly B12 injections of 1,000 micrograms.
The vitamin B12 injections are administered into the muscle (intramuscularly) or under the skin (subcutaneous) and should NOT be administered intravenously.
The most widely used form of vitamin B12 injections is cyanocobalamin. It is a man-made form of B12 that produces the same activity and function as B12 sources found in foods.
The cyanocobalamin is rapidly absorbed from intramuscular injections and the compound levels in the blood usually reach a peak within one hour.
Approximately 50 to 98 percent of b12 injection dosage may appear in the urine within 48 hours.
Methylcobalamin and Hydroxcobalamin are other forms that share the same cobalamin molecular structure and may be more effective for specific treatments.
For example, Hydroxcobalamin is often the preferred B12 form in the treatment of cyanide poisoning.
The vitamin B12 injection dosage listed here is based on research, traditional use and the opinion of experts but no single recommendation fits all patients.
Furthermore, products may contain variable ingredients within same branding or between different manufacturers.
Product labels should always be read before starting therapy and the vitamin B12 injection dosage that’s best for you should be discussed with your healthcare professional.
Vitamin B12 injection Dosage Warnings
While vitamin B12 injections are generally safe and pose very little risk to overdose, there are reported side effects, drug interactions and disease interactions that can be mild to fatal.
Patient’s who are allergic to cobalt or have a family history of Leber’s disease (hereditary optic nerve atrophy) should not take vitamin B12 injections.
As with all medications patients should always seek the knowledge, judgment and advice of a medical professional.
The vitamin B12 injection dosage recommendations listed below are for adults 18 years and older should be considered only as a supplement to, and not a substitute for the expert advice of a healthcare professional.
Typical Vitamin B12 Injection Dosage and Indications
After a treatment plan for a B12 deficiency has been established, it is important to have follow-up tests.
Serum vitamin B12 measurements can help determine the patient’s response to treatment and ensure the proper vitamin B12 injection dosage is administered.